Nkx1-2^{tm2296.1(cre/ERT2)Arte}
Targeted Allele Detail

Summary

• Symbol: Nkx1-2^{tm2296.1(cre/ERT2)Arte}
• Name: NK1 homeobox 2; targeted mutation 2296.1, TaconicArtemis
• MGI ID: MGI:6718289
• Synonyms: Nkx1-2CreER^T2
• Gene: Nkx1-2 Location: Chr7:132197968-132201366 bp, - strand Genetic Position: Chr7, 76.3 cM
• Alliance: Nkx1-2^{tm2296.1(cre/ERT2)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nkx1-2^{tm2296.1(cre/ERT2)Arte} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx1-2 (MGI:104806)

• Mutation details: The targeting construct replaced the coding sequence in exon 1 with a cre/ERT2 fusion, polyadenylation sequence, and F3-flanked puromycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:266577)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx1-2 (mouse) Summary of all recombinase alleles driven by Nkx1-2. Comparative matrix view of recombinase activities Alliance mouse Nkx1-2 gene page

Expression

In Mice Carrying this Mutation:

21 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nkx1-2 Mutation: 18 strains or lines available

References

• Original: J:266577 Rodrigo Albors A, et al., Lineage tracing of axial progenitors using Nkx1-2CreER(T2) mice defines their trunk and tail contributions. Development. 2018 Oct 2;145(19):dev164319
• All: 5 reference(s)