Pgd^tm1.1Pse
Targeted Allele Detail

Summary

• Symbol: Pgd^tm1.1Pse
• Name: phosphogluconate dehydrogenase; targeted mutation 1.1, Pankaj Seth
• MGI ID: MGI:6718292
• Synonyms: 6PGD^fl
• Gene: Pgd Location: Chr4:149234448-149251162 bp, - strand Genetic Position: Chr4, 78.96 cM
• Alliance: Pgd^tm1.1Pse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked SA-Beta-geo/Neo-pA cassette and a loxP site were inserted in the intron between exons 4 and 5 and a second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the beta-galactosidase and neomycin cassette and left exon 5 floxed. (J:306553)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgd Mutation: 21 strains or lines available

References

• Original: J:306553 Daneshmandi S, et al., Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function. Cell Rep. 2021 Mar 9;34(10):108831
• All: 2 reference(s)