Oxtr^{tm3.1(Oxtr*,cre)Knis}
Targeted Allele Detail

Summary

• Symbol: Oxtr^{tm3.1(Oxtr*,cre)Knis}
• Name: oxytocin receptor; targeted mutation 1, Katsuhiko Nishimori
• MGI ID: MGI:6718390
• Synonyms: Oxtr cDNA^HA-Ires-Cre
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^{tm3.1(Oxtr*,cre)Knis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287190
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Epitope tag, Inserted expressed sequence, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Oxtr^{tm3.1(Oxtr*,cre)Knis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oxtr (MGI:109147)

• Mutation details: The part of exon 3 was replaced with a mouse Oxtr cDNA tagged with the hemagglutinin epitope at the 3' end (Oxtr CDNA), internal ribosomal entery site (IRES) and cre, and a FRT flanked pgk-neo cassette was inserted in intron 3 via homologous recombination. The neo cassette was then removed by flippase mediated recombination. (J:287190)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oxtr (mouse) Summary of all recombinase alleles driven by Oxtr. Comparative matrix view of recombinase activities Alliance mouse Oxtr gene page

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 41 strains or lines available

References

• Original: J:287190 Hidema S, et al., Generation of Oxtr cDNA(HA)-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner. J Cell Biochem. 2016 May;117(5):1099-111
• All: 5 reference(s)