Igs2^{em1(Alb-Golm1)Jdon}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(Alb-Golm1)Jdon}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Jian Dong
• MGI ID: MGI:6718455
• Synonyms: GOLM1 Tg
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(Alb-Golm1)Jdon} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em1(Alb-Golm1)Jdon} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Golm1 (MGI:1917329)

• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing was used to insert a cassette containing the Alb promoter, the mouse Golm1 cDNA and a polyA into the locus (approximately 0.7 kb 5' of the Eif4enif1 gene and approximately 4.5 kb 3' of the Drg1 gene). (J:306528)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:306528 Ke MY, et al., Liver fibrosis promotes immune escape in hepatocellular carcinoma via GOLM1-mediated PD-L1 upregulation. Cancer Lett. 2021 Aug 10;513:14-25
• All: 1 reference(s)