Fyco1^tm1.1Tbph
Targeted Allele Detail

Summary

• Symbol: Fyco1^tm1.1Tbph
• Name: FYVE and coiled-coil domain containing 1; targeted mutation 1.1, University of Turku, Department of Physiology
• MGI ID: MGI:6718512
• Gene: Fyco1 Location: Chr9:123618565-123680964 bp, - strand Genetic Position: Chr9, 74.52 cM, cytoband F
• Alliance: Fyco1^tm1.1Tbph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306502
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector inserted into intron 5 a an FRT site, splice acceptor, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site, and loxP site. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the reporter/selection cassette and left exon 5 floxed. (J:306502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fyco1 Mutation: 44 strains or lines available

References

• Original: J:306502 Da Ros M, et al., FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules. Autophagy. 2017 Feb;13(2):302-321
• All: 1 reference(s)