Pelo^tm1.1Slac
Targeted Allele Detail

Summary

• Symbol: Pelo^tm1.1Slac
• Name: pelota mRNA surveillance and ribosome rescue factor; targeted mutation 1.1, Susan L Ackerman
• MGI ID: MGI:6718612
• Gene: Pelo Location: Chr13:115224891-115226694 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Pelo^tm1.1Slac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306384
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced a loxP site 117 bp upstream of exon 2 and a loxP site 302 bp downstream of exon 2. Cre-mediated recombination removed exon 2. (J:306384)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pelo Mutation: 15 strains or lines available

References

• Original: J:306384 Terrey M, et al., Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology. Elife. 2021 Apr 26;10:e66904
• All: 1 reference(s)