Lyz2^{em1(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lyz2^{em1(cre/ERT2)Smoc}
• Name: lysozyme 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6718613
• Synonyms: Lyz2-(2A-CreERT2-WPRE-pA), Lyz2^{em1(2A-CreERT2-WPRE-pA)Smoc}
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^{em1(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Lyz2^{em1(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyz2 (MGI:96897)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a 2A-CreERT2-WPRE-pA coexpression cassette befor the stop codon of mouse Lyz2 gene. (J:303642)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Alliance mouse Lyz2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 40 strains or lines available

References

• Original: J:303642 Gao P, et al., E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3. Nat Commun. 2021 Feb 19;12(1):1194
• All: 2 reference(s)