Tbx1^{tm1.1(cre/ERT2)Zzhg}
Targeted Allele Detail

Summary

• Symbol: Tbx1^{tm1.1(cre/ERT2)Zzhg}
• Name: T-box 1; targeted mutation 1.1, Zhen Zhang
• MGI ID: MGI:6718614
• Synonyms: Tbx1^E5C
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^{tm1.1(cre/ERT2)Zzhg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbx1^{tm1.1(cre/ERT2)Zzhg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx1 (MGI:98493)

• Mutation details: An IRES-CreERT2-polyA-SDA-Neo-SDA cassette was inserted into Xcm1 site within the exon 5, which encodes part of the T box domain resulting in a functionally null allele. The neo cassette was self-excised in the ES cells. (J:303592)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:303592 Wei L, et al., Pharyngeal epithelial deletion of Tbx1 causes caudal pharyngeal arch defect but not cardiac conotruncal anomaly. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1315-1322
• All: 1 reference(s)