Tnfsf11^{em2(cre)Htaka}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfsf11^{em2(cre)Htaka}
• Name: tumor necrosis factor (ligand) superfamily, member 11; endonuclease-mediated mutation 2, Hiroshi Takayanagi
• MGI ID: MGI:6718923
• Synonyms: RANKL-Cre
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^{em2(cre)Htaka} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase, Reporter)
• Mutation: Insertion
• Tnfsf11^{em2(cre)Htaka} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tnfsf11 (MGI:1100089)

• Mutation details: Using CRISPR/Cas9 system the Cre-P2a-Kusabira orange (KO) sequence was inserted just after the start codon of Tnfsf11. The Kusabira Orange signal was not detected in mice containing this allele by FACS analysis. (J:307029)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tnfsf11 (mouse) Summary of all recombinase alleles driven by Tnfsf11. Comparative matrix view of recombinase activities Alliance mouse Tnfsf11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:307029 Komatsu N, et al., Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. J Clin Invest. 2021 Mar 15;131(6)
• All: 1 reference(s)