Igs2^{em8(KRT14-icre)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em8(KRT14-icre)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 8, GemPharmatech Co., Ltd
• MGI ID: MGI:6718926
• Synonyms: H11^{em1Cin(hKRT14-iCre)}, H11-hKRT14-iCre, keratin14-Cre
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em8(KRT14-icre)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Igs2^{em8(KRT14-icre)Gpt} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT14 (3861)

  Krt14

  (MGI:96688)

• Mutation details: CRISPR-targeting introduced an icre driven by human KRT14 enhancer and promoter into Igs2 H11 docking site. (J:293217)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Alliance human KRT14 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:306959 Qu H, et al., Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing. Diabetes. 2021 May;70(5):1170-1184
• All: 2 reference(s)