Tg(Pomc*-cre/ERT2)#Rlb
Transgene Detail

Summary

• Symbol: Tg(Pomc*-cre/ERT2)#Rlb
• Name: transgene insertion, Robin Lovell-Badge
• MGI ID: MGI:6718949
• Synonyms: Pomc-CreERT2, Tg(Pomc-cre/ERT2)Rlb
• Transgene: Tg(Pomc*-cre/ERT2)#Rlb Location: unknown
• Alliance: Tg(Pomc*-cre/ERT2)#Rlb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pomc*-cre/ERT2)#Rlb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Pomc (24664)

  Pomc	(MGI:97742)

• Mutation details: The transgene was generated by inserting a 543bp (-480/+63) region of the mutated rat Pomc promoters (-480/+63) conferring improved pituitary expression specificity to drive the expression of CRE/ERT2. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:302308)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (rat) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities Alliance rat Pomc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:302308 Moncho-Amor V, et al., SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118
• All: 1 reference(s)