Glp1r^{tm1.1(cre)Cors}
Targeted Allele Detail

Summary

• Symbol: Glp1r^{tm1.1(cre)Cors}
• Name: glucagon-like peptide 1 receptor; targeted mutation 1.1, Cathrine Orskov
• MGI ID: MGI:6718964
• Synonyms: GLP-1r-CRE
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^{tm1.1(cre)Cors} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (No functional change, Recombinase)
• Mutation: Insertion
• Glp1r^{tm1.1(cre)Cors} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Glp1r (MGI:99571)

• Mutation details: By homologous recombination, an Internal ribosome entry site (IRES)-CRE-FRT-Neomycin-FRT cassette was inserted just downstream of the Glp1r stop codon. The generated knock-in mice were bred with a flippase (FLP)-deleter strain to remove the neomycin selection cassette. (J:302161)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Glp1r (mouse) Summary of all recombinase alleles driven by Glp1r. Comparative matrix view of recombinase activities Alliance mouse Glp1r gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 49 strains or lines available

References

• Original: J:302161 Andersen DB, et al., Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice. Endocrinology. 2021 Mar 1;162(3)
• All: 1 reference(s)