Tg(Csf2rb2-cre)252Tjmc
Transgene Detail

Summary

• Symbol: Tg(Csf2rb2-cre)252Tjmc
• Name: transgene insertion 252, Thomas J McHugh
• MGI ID: MGI:6719252
• Synonyms: Csf2rb2-Cre, SuM-Cre
• Transgene: Tg(Csf2rb2-cre)252Tjmc Location: unknown
• Alliance: Tg(Csf2rb2-cre)252Tjmc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Csf2rb2-cre)252Tjmc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Csf2rb2 (MGI:1339760)

• Mutation details: The bacterial artificial chromosome (BAC) RP23-233L7 containing mouse the colony stimulating factor 2 receptor, beta2 (Csf2rb2) gene was modified to insert a Cre-FRT-Amp-FRT cassette at the start site of Csf2rb2 translation. The ampicillin (Amp) marker was deleted and the Cre-modified BAC's were confirmed, purified, and injected into C57BL/6 fertilized pronuclei. Four founders (lines 252, 267, 271, 272) were generated. The line 252 Csf2rb2-Cre line was determined to express Cre selectively supramammillary area of the hypothalamus using immunohistochemistry with the anti-Cre recombinase antibody, and used for analyses. (J:297389)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Csf2rb2 (mouse) Summary of all recombinase alleles driven by Csf2rb2. Comparative matrix view of recombinase activities Alliance mouse Csf2rb2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:297389 Chen S, et al., A hypothalamic novelty signal modulates hippocampal memory. Nature. 2020 Oct;586(7828):270-274
• All: 2 reference(s)