Calcr^{tm1.1(cre)Mgmj}
Targeted Allele Detail

Summary

• Symbol: Calcr^{tm1.1(cre)Mgmj}
• Name: calcitonin receptor; targeted mutation 1.1, Martin G Myers, Jr
• MGI ID: MGI:6719375
• Synonyms: Calcr^cre
• Gene: Calcr Location: Chr6:3685680-3764714 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Calcr^{tm1.1(cre)Mgmj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260503
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Calcr^{tm1.1(cre)Mgmj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Calcr (MGI:101950)

• Mutation details: A targeting plasmid containing the porcine teschoviral 2A cleavage sequence linked to Cre recombinase and a Frt-flanked neomycin resistance gene replacing the stop codon of the Calcr gene in a bacterial artificial chromosome (RP24-193M22) was used for embryonic stem cell targeting. Chimeric animals generated were mated to Flp-deleter mice to remove the neomycin selection cassette. (J:260503)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Calcr (mouse) Summary of all recombinase alleles driven by Calcr. Comparative matrix view of recombinase activities Alliance mouse Calcr gene page

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Calcr Mutation: 59 strains or lines available

References

• Original: J:260503 Pan W, et al., Essential Role for Hypothalamic Calcitonin ReceptorExpressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 Apr 1;159(4):1860-1872
• All: 5 reference(s)