Gt(ROSA)26Sor^{tm6(dre/PGR*)Dwi}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm6(dre/PGR*)Dwi}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Douglas J Winton
• MGI ID: MGI:6719400
• Synonyms: RDre^Pr
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm6(dre/PGR*)Dwi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301641
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm6(dre/PGR*)Dwi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A splice acceptor site was inserted immediately before the Dre and the mutated human progesterone receptor (PGR) consisting of the Ru486 responsive mutant hormone-binding domain hPR891 was fused to the N-terminus of Dre sequence followed by a bovine growth hormone (BGH) polyadenylation signal and PGK-Puro selection cassette. The targeting vector was inserted into a Gt(ROSA)26Sor site by homologous recombination in ES cells. (J:301641)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:301641 Thorsen AS, et al., Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing. Dis Model Mech. 2020 Oct 22;:dmm046706
• All: 1 reference(s)