Rr80^em1Jwsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr80^em1Jwsk
• Name: regulatory region 80; endonuclease-mediated mutation 1, Joanna Wysocka
• MGI ID: MGI:6720282
• Synonyms: mEC1.45del-founder1
• Gene: Rr80 Location: Chr11:111456657-111460228 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr80^em1Jwsk page

Mutation origin

• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 3572 bp, including the enhancer cluster 1.45 (EC1.45) located upstream 1.45 Mb upstream of Sox9. (J:306395)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr80 Mutation: 0 strains or lines available

References

• Original: J:306395 Long HK, et al., Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder. Cell Stem Cell. 2020 Nov 5;27(5):765-783.e14
• All: 1 reference(s)