Scgb1a1^{tm1.1(icre)Fjd}
Targeted Allele Detail

Summary

• Symbol: Scgb1a1^{tm1.1(icre)Fjd}
• Name: secretoglobin, family 1A, member 1; targeted mutation 1.1, Franco J DeMayo
• MGI ID: MGI:6720287
• Synonyms: CCSP^iCre, Scgb1a1-cre
• Gene: Scgb1a1 Location: Chr19:9061006-9065320 bp, - strand Genetic Position: Chr19, 6.05 cM, cytoband A
• Alliance: Scgb1a1^{tm1.1(icre)Fjd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185603
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Scgb1a1^{tm1.1(icre)Fjd} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scgb1a1 (MGI:98919)

• Mutation details: The improved cre (icre) and FRT-flanked neomycin resistance cassette were inserted at the translation initation site. Activity was observed the majority of airway epithelial cells including the trachea, the bronchi and bronchioles. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:185603)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scgb1a1 (mouse) Summary of all recombinase alleles driven by Scgb1a1. Alliance mouse Scgb1a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scgb1a1 Mutation: 29 strains or lines available

Notes

The version of this allele that contains/ does not contain the neomycin selection cassette, Scgb1a1^tm1(icre)Fjd, has been analyzed.

References

• Original: J:185603 Li S, et al., Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9
• All: 3 reference(s)