Hecw2^tm1.1Fhe
Targeted Allele Detail

Summary

• Symbol: Hecw2^tm1.1Fhe
• Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; targeted mutation 1.1, Fuchu He
• MGI ID: MGI:6720293
• Synonyms: NEDL2^LacZ
• Gene: Hecw2 Location: Chr1:53846031-54234193 bp, - strand Genetic Position: Chr1, 26.99 cM
• Alliance: Hecw2^tm1.1Fhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306367
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 7, a floxed neomycin resistance cassette with a 5 FRT site, IRES, lacZ reporter gene, and FRT were inserted downstream of exon 5. Cre-mediated recombination removed exon 5 through 7 and replaced them with an IRES and lacZ reporter gene. (J:306367)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hecw2 Mutation: 67 strains or lines available

References

• Original: J:306367 Wei R, et al., NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell Signal. 2015 Mar;27(3):578-86
• All: 2 reference(s)