Wdr45^em1Wrst
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wdr45^em1Wrst
• Name: WD repeat domain 45; endonuclease-mediated mutation 1, Wolfgang Wurst
• MGI ID: MGI:6720362
• Gene: Wdr45 Location: ChrX:7588212-7594439 bp, + strand Genetic Position: ChrX, 3.48 cM
• Alliance: Wdr45^em1Wrst page

Mutation origin

• Strain of Origin: (FVB x C57BL/6N)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting of exon 2 deleted 20 bp and results in a frameshift and premature stop codon 35 amino acids after the methionine (NM_001290792.1, GRCm38). (J:307284)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wdr45 Mutation: 20 strains or lines available

References

• Original: J:307284 Biagosch CA, et al., A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse. Mamm Genome. 2021 May 27
• All: 1 reference(s)