Col1a2^{em1(cre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Col1a2^{em1(cre/ERT2)Bzsh}
• Name: collagen, type I, alpha 2; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:6721050
• Synonyms: Col1a2-2A-CreER
• Gene: Col1a2 Location: Chr6:4505618-4541543 bp, + strand Genetic Position: Chr6, 1.81 cM
• Alliance: Col1a2^{em1(cre/ERT2)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Col1a2^{em1(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Col1a2 (MGI:88468)

• Mutation details: Using the CRISPR/Cas9 technology, the line was generated by inserting a cDNA encoding cre/ERT2 recombinase into the translational stop codon of the Col1a2 gene, following endogenous Col1a2 by the self-cleaving peptide 2A sequence. (J:248362)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col1a2 (mouse) Summary of all recombinase alleles driven by Col1a2. Comparative matrix view of recombinase activities Alliance mouse Col1a2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a2 Mutation: 120 strains or lines available

References

• Original: J:248362 He L, et al., Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017 Aug 01;127(8):2968-2981
• All: 3 reference(s)