Pdgfra^{em1(dre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pdgfra^{em1(dre/ERT2)Bzsh}
• Name: platelet derived growth factor receptor, alpha polypeptide; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:6721052
• Synonyms: Pdgfra-DreER
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^{em1(dre/ERT2)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pdgfra^{em1(dre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfra (MGI:97530)

• Mutation details: Using the CRISPR/Cas9 technology, the line was generated by inserting a cDNA encoding dre/ERT2 recombinase after the translational stop codon of the Pdgfra gene. (J:248362)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfra (mouse) Summary of all recombinase alleles driven by Pdgfra. Comparative matrix view of recombinase activities Alliance mouse Pdgfra gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:248362 He L, et al., Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017 Aug 01;127(8):2968-2981
• All: 2 reference(s)