Matn4^tm1.1Asz
Targeted Allele Detail

Summary

• Symbol: Matn4^tm1.1Asz
• Name: matrilin 4; targeted mutation 1.1, Atilla Aszodi
• MGI ID: MGI:6721399
• Gene: Matn4 Location: Chr2:164231313-164247080 bp, - strand Genetic Position: Chr2, 85.16 cM
• Alliance: Matn4^tm1.1Asz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237230
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin-TKcontaining selection cassette was inserted into the second intron and a single loxP site into the third intron. Cre-mediated recombination in ES cells resulted in the removal of exon 1 encompassing the translation initiation codon and the selection cassette. (J:237230)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Matn4^tm1.1Asz/Matn4^tm1.1Asz	B6.129-Matn4^tm1.1Asz
cx2	Matn1^tm1Ref/Matn1^tm1Ref Matn2^tm1Asz/Matn2^tm1Asz Matn3^tm1Asz/Matn3^tm1Asz Matn4^tm1.1Asz/Matn4^tm1.1Asz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
cellular	√	√
increased hematopoietic stem cell proliferation	√	√
hematopoietic system	√	√
increased hematopoietic stem cell proliferation	√	√
decreased double-positive T cell number		√
increased megakaryocyte cell number		√
decreased erythrocyte cell number		√
increased granulocyte number		√
decreased hematopoietic stem cell number	√	√
homeostasis/metabolism		√
abnormal physiological response to xenobiotic		√
immune system		√
decreased double-positive T cell number		√
increased granulocyte number		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Matn4 Mutation: 17 strains or lines available

References

• Original: J:237230 Uckelmann H, et al., Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. J Exp Med. 2016 Sep 19;213(10):1961-71
• All: 2 reference(s)