Tg(Tbx21-cre)1Yyos
Transgene Detail

Summary

• Symbol: Tg(Tbx21-cre)1Yyos
• Name: transgene insertion 1, Yoshihiro Yoshihara
• MGI ID: MGI:6721441
• Synonyms: Cla-Cre
• Transgene: Tg(Tbx21-cre)1Yyos Location: unknown
• Alliance: Tg(Tbx21-cre)1Yyos page

Transgene origin

• Strain of Origin: B6D2F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tbx21-cre)1Yyos expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx21 (MGI:1888984)

• Mutation details: The transgene consisting of the 5.0-kb upstream enhancer/promoter region sequence of the mouse Tbx21 gene was fused to the bacteriophage P1 Cre recombinase gene with the human -globin gene intron and simian virus 40 polyadenylation signal driving cre expression specifically in the mitral/tufted cells of the olfactory bulb. The DNA construct was purified and initialized then injected into the pronucleus of fertilized eggs that were obtained from crossing C57BL/6J and DBA/2J mice. Seven transgenic mouse lines were established and one (line no. 1) showed ectopic expression of Cre protein specifically in the claustrum and was used for the study. (J:293062)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx21 (mouse) Summary of all recombinase alleles driven by Tbx21. Comparative matrix view of recombinase activities Alliance mouse Tbx21 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:293062 Narikiyo K, et al., The claustrum coordinates cortical slow-wave activity. Nat Neurosci. 2020 Jun;23(6):741-753
• All: 1 reference(s)