Tor1a^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tor1a^em1Bcgen
• Name: torsin family 1, member A (torsin A); endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:6723799
• Synonyms: Tet(TorA)
• Gene: Tor1a Location: Chr2:30850639-30857945 bp, - strand Genetic Position: Chr2, 21.77 cM
• Alliance: Tor1a^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a floxed STOP cassette and tetracycline response element upstream of exon 1. (J:307028)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tor1a Mutation: 24 strains or lines available

References

• Original: J:307028 Li J, et al., TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia. J Clin Invest. 2021 Mar 15;131(6)
• All: 1 reference(s)