Exo5^em1Qsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Exo5^em1Qsh
• Name: exonuclease 5; endonuclease-mediated mutation 1, Qinghua Shi
• MGI ID: MGI:6723809
• Gene: Exo5 Location: Chr4:120778399-120782202 bp, - strand Genetic Position: Chr4, 56.65 cM
• Alliance: Exo5^em1Qsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation is a 2 bp deletion in exon 2 (c.792-793delTG) generated by CRISPR/Cas9 genome editing technology. This deletion results in a frameshift mutation, and Western blot analysis confirmed the lack of full length protein in mutant tissue. (J:307534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Exo5 Mutation: 22 strains or lines available

References

• Original: J:307534 Zaman Q, et al., Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse. Gene. 2021 Feb 15;769:145254
• All: 1 reference(s)