Sox2^{tm1.1(cre/ERT2)Ykaw}
Targeted Allele Detail

Summary

• Symbol: Sox2^{tm1.1(cre/ERT2)Ykaw}
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Yoshiya Kawaguchi
• MGI ID: MGI:6724015
• Synonyms: Sox2^CreERT2
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^{tm1.1(cre/ERT2)Ykaw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301269
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Sox2^{tm1.1(cre/ERT2)Ykaw} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: A CreERT2-pA-PGK-Bsd-pA replaced most of exon 1 after the first ATG of the Sox2 gene via homologous recombination in ES cells. Recombination removed the selection cassette. (J:301269)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:301269 Sankoda N, et al., Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice. Nat Commun. 2021 Jan 25;12(1):560
• All: 1 reference(s)