Tg(Foxa2/Sox9-cre,-lacZ)#Vleu
Transgene Detail

Summary

• Symbol: Tg(Foxa2/Sox9-cre,-lacZ)#Vleu
• Name: transgene insertion, Victor Leung
• MGI ID: MGI:6724034
• Synonyms: Foxa2mNE-Cre, Tg(Rr241/Sox9-cre,-lacZ)#Vleu
• Transgene: Tg(Foxa2/Sox9-cre,-lacZ)#Vleu Location: unknown
• Alliance: Tg(Foxa2/Sox9-cre,-lacZ)#Vleu page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase, Reporter)
• Mutation: Insertion
• Tg(Foxa2/Sox9-cre,-lacZ)#Vleu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxa2 (MGI:1347476)

• Mutation details: This transgene contains the 520bp minimal notochord enhancer (Rr241) of the mouse Foxa2 gene fused to the upstream genomic sequence of the Sox9 gene followed by replacing the coding region of Sox9 with the Cre recombinase gene and an IRES-lacZ reporter inserted between the Cre Stop codon and the Sox9 polyadenylation sequence. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:301098)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa2 (mouse) Summary of all recombinase alleles driven by Foxa2. Comparative matrix view of recombinase activities Alliance mouse Foxa2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:301098 Au TYK, et al., Transformation of resident notochord-descendent nucleus pulposus cells in mouse injury-induced fibrotic intervertebral discs. Aging Cell. 2020 Nov;19(11):e13254
• All: 4 reference(s)