Lrig1^{tm2.1(icre/ERT2)Mrc}
Targeted Allele Detail

Summary

• Symbol: Lrig1^{tm2.1(icre/ERT2)Mrc}
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 2.1, Mario R Capecchi
• MGI ID: MGI:6724057
• Synonyms: Lrig1^T2A-iCreERT2
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^{tm2.1(icre/ERT2)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286603
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Lrig1^{tm2.1(icre/ERT2)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrig1 (MGI:107935)

• Mutation details: The targeting construct contains a T2A-sfGFP-icre/ERT2-FRT-neo-FRT cassette, which replaces the stop codon just before the 3' untranslated region. The GFP fluorescence is not detectable because the GFP fluorescence is dim. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:286603)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrig1 (mouse) Summary of all recombinase alleles driven by Lrig1. Comparative matrix view of recombinase activities Alliance mouse Lrig1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 50 strains or lines available

References

• Original: J:286603 Nam HS, et al., Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural Dev. 2020 Mar 17;15(1):3
• All: 2 reference(s)