Itgax^{em1(dre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Itgax^{em1(dre/ERT2)Smoc}
• Name: integrin alpha X; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6724221
• Synonyms: Cd11c-2A-DreER, Itgax^{em1(2A-DreERT2)Smoc}
• Gene: Itgax Location: Chr7:127728719-127749829 bp, + strand Genetic Position: Chr7, 69.98 cM
• Alliance: Itgax^{em1(dre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Itgax^{em1(dre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Itgax (MGI:96609)

• Mutation details: A 2A-DreERT2 expression cassette was knocked into the Itgax gene stop codon site via CRISPR/Cas mediated recombination. (J:238766, J:304636)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Itgax (mouse) Summary of all recombinase alleles driven by Itgax. Alliance mouse Itgax gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgax Mutation: 76 strains or lines available

References

• Original: J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2
• All: 2 reference(s)