Hcn4^{em1(dre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hcn4^{em1(dre/ERT2)Smoc}
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6724251
• Synonyms: Hcn4-DreER, Hcn4^{em1(kozak-DreER-WPRE-A)Smoc}
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^{em1(dre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hcn4^{em1(dre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hcn4 (MGI:1298209)

• Mutation details: A kozak-DreER-WPRE-pA expression cassette was knocked into the Hcn4 gene start codon site via CRISPR/Cas9 mediated recombination. (J:238766, J:304636)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hcn4 (mouse) Summary of all recombinase alleles driven by Hcn4. Alliance mouse Hcn4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 67 strains or lines available

References

• Original: J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2
• All: 3 reference(s)