Tsga10^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tsga10^em2Smoc
• Name: testis specific 10; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:6725810
• Synonyms: Tsga10^-
• Gene: Tsga10 Location: Chr1:37793857-37905510 bp, - strand Genetic Position: Chr1, 15.88 cM, cytoband B
• Alliance: Tsga10^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 technology, the 484 bp from the exon 7 and the flanking intronic regions of the Tsga10 gene resulting in frameshift mutations. It is a null allele, however, only one infertile heterozygous male founder was generated and no subsequent breeding was carried out. (J:238766, J:307710)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsga10 Mutation: 35 strains or lines available

References

• Original: J:307710 Luo G, et al., Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice. Andrology. 2021 Jan;9(1):368-375
• All: 2 reference(s)