Oxt^{tm1.1(flpo)Cya}
Targeted Allele Detail

Summary

• Symbol: Oxt^{tm1.1(flpo)Cya}
• Name: oxytocin; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6726072
• Synonyms: OT-2A-Flp KI, Oxt^{tm1.1(flpo)Cgen}
• Gene: Oxt Location: Chr2:130418093-130418974 bp, + strand Genetic Position: Chr2, 63.24 cM
• Alliance: Oxt^{tm1.1(flpo)Cya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301094
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Oxt^{tm1.1(flpo)Cya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oxt (MGI:97453)

• Mutation details: The stop codon in exon 3 of the endogenous oxytocin gene (Oxt) was replaced with a 2A-flpo construct. A neo selection cassette was removed by cre recombination. (J:301094)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oxt (mouse) Summary of all recombinase alleles driven by Oxt. Comparative matrix view of recombinase activities Alliance mouse Oxt gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxt Mutation: 20 strains or lines available

References

• Original: J:301094 Nardou R, et al., Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature. 2019 May;569(7754):116-120
• All: 2 reference(s)