Tg(Runx1/Hspa1a-cre/ERT2)#Itoy
Transgene Detail

Summary

• Symbol: Tg(Runx1/Hspa1a-cre/ERT2)#Itoy
• Name: transgene insertion, Yoshiaki Ito
• MGI ID: MGI:6726413
• Synonyms: eR1-CreERT2, eRx1-CreERT
• Transgene: Tg(Runx1/Hspa1a-cre/ERT2)#Itoy Location: unknown
• Alliance: Tg(Runx1/Hspa1a-cre/ERT2)#Itoy page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Runx1/Hspa1a-cre/ERT2)#Itoy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Runx1 (MGI:99852)

• Mutation details: The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of cre/ERT2. More than 10 founder lines were generated. The line TG(5-2) with higher copy number and TG(3-7) with lower copy number used for studies. Although the former had higher Cre recombinase activity than the latter, the results obtained using these lines were qualitatively indistinguishable. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:299420)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Runx1 (mouse) Summary of all recombinase alleles driven by Runx1. Comparative matrix view of recombinase activities Alliance mouse Runx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:299420 Matsuo J, et al., Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Gastroenterology. 2017 Jan;152(1):218-231.e14
• All: 6 reference(s)