Gabra1^em1(cre)Lbrl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gabra1^em1(cre)Lbrl
• Name: gamma-aminobutyric acid type A receptor subunit alpha 1; endonuclease-mediated mutation 1, Stephen Liberles
• MGI ID: MGI:6726586
• Synonyms: Gabra1-ires-Cre
• Gene: Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
• Alliance: Gabra1^em1(cre)Lbrl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Gabra1^em1(cre)Lbrl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gabra1 (MGI:95613)

• Using the CRISPR/Cas9 technology, ires-Cre was inserted into the 3' UTR of the mouse Gabra1 locus. (J:298576)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gabra1 (mouse) Summary of all recombinase alleles driven by Gabra1. Comparative matrix view of recombinase activities Alliance mouse Gabra1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra1 Mutation: 48 strains or lines available

References

• Original: J:298576 Prescott SL, et al., An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents. Cell. 2020 Apr 30;181(3):574-589.e14
• All: 2 reference(s)