Atoh7^{tm3(cre/ERT2)Xmu}
Targeted Allele Detail

Summary

• Symbol: Atoh7^{tm3(cre/ERT2)Xmu}
• Name: atonal bHLH transcription factor 7; targeted mutation 3, Xiuqian Mu
• MGI ID: MGI:6727035
• Synonyms: Atoh7^{zsGreenCreERT2}
• Gene: Atoh7 Location: Chr10:62935564-62937059 bp, + strand Genetic Position: Chr10, 32.54 cM
• Alliance: Atoh7^{tm3(cre/ERT2)Xmu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297659
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Atoh7^{tm3(cre/ERT2)Xmu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh7 (MGI:1355553)

• Mutation details: The zsGreen-T2A-CreERT2-SV40 poly(A)-LoxP-Neo-LoxP cassette replaced Atoh7 ORF by homologous recombination in the ES cells. It is a null allele designed to express both zsGreen and CreERT2 from the Atoh7 promoter. (J:297659)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh7 (mouse) Summary of all recombinase alleles driven by Atoh7. Comparative matrix view of recombinase activities Alliance mouse Atoh7 gene page

Expression

In Mice Carrying this Mutation:

16 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh7 Mutation: 9 strains or lines available

References

• Original: J:297659 Ge Y, et al., Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins. Dev Dyn. 2020 Aug 2
• All: 2 reference(s)