Tg(VIPR2/Hspa1b-cre/ERT2)1Dlee
Transgene Detail

Summary

• Symbol: Tg(VIPR2/Hspa1b-cre/ERT2)1Dlee
• Name: transgene insertion 1, Daekee Lee
• MGI ID: MGI:6727058
• Synonyms: VIPR2-ERT2CreERT2-001
• Transgene: Tg(VIPR2/Hspa1b-cre/ERT2)1Dlee Location: unknown
• Alliance: Tg(VIPR2/Hspa1b-cre/ERT2)1Dlee page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(VIPR2/Hspa1b-cre/ERT2)1Dlee expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  VIPR2 (7434)

  Vipr2

  (MGI:107166)

• Mutation details: A transgene consisting of hs1753 (chr7:158,888,320-158,891,362) enhancer element located in intron 4 of human VIPR2 gene subcloned into Hsp68 promoter fused with ERT2CreERT2-pA to drive expression of cre in response to tamoxifen in developing heart. A total of nine transgenic founders lines 1, 17, 20, 22, 23, 29, 30, 32, 33 were obtained. All transgenic lines showed heart-specific cre activity when bred to a cre reporter mouse. Transgenic line 001 exhibited the strongest expression of the reporter gene and was used for further studies. (J:297289)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	VIPR2 (human) Summary of all recombinase alleles driven by VIPR2. Comparative matrix view of recombinase activities Alliance human VIPR2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:297289 Chin HJ, et al., Tamoxifen-inducible cardiac-specific Cre transgenic mouse using VIPR2 intron. Lab Anim Res. 2020;36:31
• All: 1 reference(s)