Cdkn2a^{tm2.1(cre/ERT2)Dvb}
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^{tm2.1(cre/ERT2)Dvb}
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Dmitry V Bulavin
• MGI ID: MGI:6727120
• Synonyms: p16-CreERt2
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^{tm2.1(cre/ERT2)Dvb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Cdkn2a^{tm2.1(cre/ERT2)Dvb} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdkn2a (MGI:104738)

• Mutation details: An T2A-Cre/ERT2-T2A-TK-T2A-mCherry cassette was introduced at the end of the last exon of the Cdkn2a (p16Ink4) gene by homologous recombination in the ES cells. The Frt-loxed Neo cassette was removed by crossing with FLP deleter. (J:296551)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdkn2a (mouse) Summary of all recombinase alleles driven by Cdkn2a. Comparative matrix view of recombinase activities Alliance mouse Cdkn2a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:296551 Grosse L, et al., Defined p16(High) Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020 Jul 7;32(1):87-99.e6
• All: 1 reference(s)