Gm614tm1.1Cya
Targeted Allele Detail
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Symbol: |
Gm614tm1.1Cya |
Name: |
predicted gene 614; targeted mutation 1.1, Cyagen Biosciences |
MGI ID: |
MGI:6727377 |
Synonyms: |
Gm614fl, Gm614tm1.1Cgen |
Gene: |
Gm614 Location: ChrX:100304982-100307598 bp, - strand Genetic Position: ChrX, 43.9 cM
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Alliance: |
Gm614tm1.1Cya page
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Germline Transmission: |
Earliest citation of germline transmission:
J:307345
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream of the gene and a second loxP site into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 1 floxed.
(J:307345)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gm614 Mutation: |
5 strains or lines available
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Original: |
J:307345 He Y, et al., Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. Front Immunol. 2020;11:585726 |
All: |
1 reference(s) |
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