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Gm614tm1.1Cya
Targeted Allele Detail
Summary
Symbol: Gm614tm1.1Cya
Name: predicted gene 614; targeted mutation 1.1, Cyagen Biosciences
MGI ID: MGI:6727377
Synonyms: Gm614fl, Gm614tm1.1Cgen
Gene: Gm614  Location: ChrX:100304982-100307598 bp, - strand  Genetic Position: ChrX, 43.9 cM
Alliance: Gm614tm1.1Cya page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:307345
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream of the gene and a second loxP site into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 1 floxed. (J:307345)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gm614 Mutation:  5 strains or lines available
References
Original:  J:307345 He Y, et al., Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. Front Immunol. 2020;11:585726
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory