Tg(Gcg-icre/ERT2)9Reim
Transgene Detail

Summary

• Symbol: Tg(Gcg-icre/ERT2)9Reim
• Name: transgene insertion 9, Frank Reimann
• MGI ID: MGI:6727379
• Synonyms: Gcg-CreER^T2, GLU-CreERT2-09
• Transgene: Tg(Gcg-icre/ERT2)9Reim Location: unknown
• Alliance: Tg(Gcg-icre/ERT2)9Reim page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Gcg-icre/ERT2)9Reim expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gcg (MGI:95674)

• Mutation details: The transgene based on murine BAC clone (RP23-343C17) containing the sequence between the proglucagon start codon in exon 2 and stop codon in exon 6 was used to express iCreERT2 under the control of the proglucagon promoter. Initially, two transgenic lines 9 and 17 were established both with an estimated transgene copy number of one. The initial characterization did not reveal any differences and line 9 was used in the study. (J:295333)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gcg (mouse) Summary of all recombinase alleles driven by Gcg. Comparative matrix view of recombinase activities Alliance mouse Gcg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:295333 Campbell JR, et al., Essential Role of Syntaxin-Binding Protein-1 in the Regulation of Glucagon-Like Peptide-1 Secretion. Endocrinology. 2020 May 1;161(5)
• All: 2 reference(s)