Nts^{tm1(flpo)Giml}
Targeted Allele Detail

Summary

• Symbol: Nts^{tm1(flpo)Giml}
• Name: neurotensin; targeted mutation 1, Gina M Leinninger
• MGI ID: MGI:6727386
• Synonyms: Nts^FlpO
• Gene: Nts Location: Chr10:102317617-102326294 bp, - strand Genetic Position: Chr10, 53.56 cM, cytoband D1
• Alliance: Nts^{tm1(flpo)Giml} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294688
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nts^{tm1(flpo)Giml} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nts (MGI:1328351)

• Mutation details: An IRES-FlpO sequence was inserted into the 3' UTR of the Nts gene between the stop codon and the polyadenylation sequence. An frt-flanked neo cassette was inserted upstream of the IRES-FlpO for selection purposes. (J:294688)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nts (mouse) Summary of all recombinase alleles driven by Nts. Comparative matrix view of recombinase activities Alliance mouse Nts gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nts Mutation: 18 strains or lines available

References

• Original: J:294688 Brown JA, et al., Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration. Sci Rep. 2019 Feb 12;9(1):1873
• All: 1 reference(s)