Taf1^em2Ems
Endonuclease-mediated Allele Detail

Summary

• Symbol: Taf1^em2Ems
• Name: TATA-box binding protein associated factor 1; endonuclease-mediated mutation 2, Elizabeth M Simpson
• MGI ID: MGI:6728059
• Synonyms: Taf1^fl
• Gene: Taf1 Location: ChrX:100576335-100644635 bp, + strand Genetic Position: ChrX, 44.29 cM
• Alliance: Taf1^em2Ems page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing was used to insert loxP sites flanking exon 8 (with respect to transcripts Taf1-202 or -206) or exons 8-9 (with respect to transcript Taf1-201). (J:352096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Taf1 Mutation: 12 strains or lines available

References

• Original: J:352096 Crombie EM, et al., Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders. Dis Model Mech. 2024 Jul 1;17(7)
• All: 1 reference(s)