Txndc5^em1Ntuh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Txndc5^em1Ntuh
• Name: thioredoxin domain containing 5; endonuclease-mediated mutation 1, National Taiwan University Hospital
• MGI ID: MGI:6728079
• Gene: Txndc5 Location: Chr13:38684242-38712800 bp, - strand Genetic Position: Chr13, 18.27 cM
• Alliance: Txndc5^em1Ntuh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 6.8 kb spanning exon 2 through 3. (J:307898)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txndc5 Mutation: 26 strains or lines available

References

• Original: J:307898 Shih YC, et al., Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circ Res. 2018 Apr 13;122(8):1052-1068
• All: 1 reference(s)