Prxl2b^tm1.2Ksak
Targeted Allele Detail

Summary

• Symbol: Prxl2b^tm1.2Ksak
• Name: peroxiredoxin like 2B; targeted mutation 1.2, Kenji Sakimura
• MGI ID: MGI:6728799
• Synonyms: PM/PGFS KO, Prxl2b^tm1Dfwo
• Gene: Prxl2b Location: Chr4:154980884-154983522 bp, - strand Genetic Position: Chr4, 85.67 cM
• Alliance: Prxl2b^tm1.2Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307536
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 139 bp upstream of exon 2 and an FRT-flanked PGK promoter-driven neopoly cassette and second loxP site were inserted downstream of exon 3. Cre-mediated recombination deleted exons 2 and 3 and the selection cassette. qPCR of anterior eye segments and inguinal fat pads confirmed absence of transcript in homozygotes. (J:307536)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prxl2b Mutation: 22 strains or lines available

References

• Original: J:307536 Bertrand JA, et al., Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure. Prostaglandins Leukot Essent Fatty Acids. 2021 Feb;165:102235
• All: 1 reference(s)