Mchr1^em2Mctr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mchr1^em2Mctr
• Name: melanin-concentrating hormone receptor 1; endonuclease-mediated mutation 2, Jeremy McIntyre
• MGI ID: MGI:6729886
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^em2Mctr page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to create an 8 bp deletion. Immunostaining with an antibody that recognizes the C-terminal tail, demonstrates a loss of staining in brain sections of the olfactory bulb. (J:308509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 25 strains or lines available

References

• Original: J:308509 Jasso KR, et al., An N-terminal fusion allele to study melanin concentrating hormone receptor 1. Genesis. 2021 Jun 14
• All: 1 reference(s)