Ppdpf^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Ppdpf^tm1Nju
• Name: pancreatic progenitor cell differentiation and proliferation factor; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6739867
• Synonyms: PPDPF^f
• Gene: Ppdpf Location: Chr2:180829040-180830564 bp, + strand Genetic Position: Chr2, 103.62 cM
• Alliance: Ppdpf^tm1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 1 to 5 were flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted after exon 5 but before the second loxP site. (J:307283)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppdpf Mutation: 25 strains or lines available

References

• Original: J:307283 Ma N, et al., PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Nat Commun. 2021 May 24;12(1):3059
• All: 2 reference(s)