Lrp4^{tm1.1(GFP/cre/ERT2)Gan}
Targeted Allele Detail

Summary

• Symbol: Lrp4^{tm1.1(GFP/cre/ERT2)Gan}
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Lin Gan
• MGI ID: MGI:6739898
• Synonyms: Lrp4-Cre^ERT2
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^{tm1.1(GFP/cre/ERT2)Gan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291055
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Lrp4^{tm1.1(GFP/cre/ERT2)Gan} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrp4 (MGI:2442252)

• Mutation details: A targeting vector containing a 3' FRT flanked neo cassette and P2A-GFP-CreERT2 cassette was inserted to exon 38 of the Lrp4 gene via homologous recombination in C57BL/6J-derived embryonic stem cells. Heterozygous animals were crossed subsequently to FLP recombinase expressing mice to remove the FRT site flanked PGK-neo cassette. (J:291055)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrp4 (mouse) Summary of all recombinase alleles driven by Lrp4. Comparative matrix view of recombinase activities Alliance mouse Lrp4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 98 strains or lines available

References

• Original: J:291055 Zhang H, et al., A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Abeta Clearance. J Neurosci. 2020 Jul 8;40(28):5347-5361
• All: 2 reference(s)