Grpr^em2(flpo)Ygs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grpr^em2(flpo)Ygs
• Name: gastrin releasing peptide receptor; endonuclease-mediated mutation 2, Yan-Gang Sun
• MGI ID: MGI:6740372
• Synonyms: GRPR-Flpo
• Gene: Grpr Location: ChrX:162296900-162332673 bp, - strand Genetic Position: ChrX, 75.63 cM
• Alliance: Grpr^em2(flpo)Ygs page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Grpr^em2(flpo)Ygs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grpr (MGI:95836)

• Using CRISPR/Cas9 technology, a 2A-flpo cassette was inserted in the last exon of Grpr gene. (J:308660)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grpr (mouse) Summary of all recombinase alleles driven by Grpr. Comparative matrix view of recombinase activities Alliance mouse Grpr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grpr Mutation: 14 strains or lines available

References

• Original: J:308660 Liu MZ, et al., Synaptic control of spinal GRPR(+) neurons by local and long-range inhibitory inputs. Proc Natl Acad Sci U S A. 2019 Dec 5
• All: 5 reference(s)