Megf10^{tm1.1(cre)Jnk}
Targeted Allele Detail

Summary

• Symbol: Megf10^{tm1.1(cre)Jnk}
• Name: multiple EGF-like-domains 10; targeted mutation 1.1, Jeremy N Kay
• MGI ID: MGI:6740603
• Synonyms: Megf10^Cre
• Gene: Megf10 Location: Chr18:57266162-57430539 bp, + strand Genetic Position: Chr18, 31.5 cM
• Alliance: Megf10^{tm1.1(cre)Jnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290493
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (No functional change, Recombinase)
• Mutation: Insertion
• Megf10^{tm1.1(cre)Jnk} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Megf10 (MGI:2685177)

• Mutation details: A cre recombinase expression cassette was inserted at the end of the Megf10 coding exon with the two reading frames separated by a T2A sequence. The neo selection cassette was subsequently removed. (J:290493)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Megf10 (mouse) Summary of all recombinase alleles driven by Megf10. Comparative matrix view of recombinase activities Alliance mouse Megf10 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Megf10 Mutation: 69 strains or lines available

References

• Original: J:290493 Peng YR, et al., Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. Neuron. 2020 Feb 5;105(3):464-474.e6
• All: 3 reference(s)