Tg(KRT5-cre/ERT2)2Blh
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre/ERT2)2Blh
• Name: transgene insertion 2, Brigid L Hogan
• MGI ID: MGI:6753172
• Synonyms: KRT5- CreERT
• Transgene: Tg(KRT5-cre/ERT2)2Blh Location: unknown
• Alliance: Tg(KRT5-cre/ERT2)2Blh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT5-cre/ERT2)2Blh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT5 (3852)

  Krt5	(MGI:96702)

• Mutation details: The 6-kb human keratin 5 (KRT5) promoter drives a cre/ERT2 cassette. The cre/ERT2 is flanked by an intron and a polyadenylation sequence from the pCI mammalian expression vector. The construct was injected into fertilized zygotes. 11 founder lines were obtained, and 2nd line that has expression in esophageal basal cells but not in tracheal cells was established. (J:152012)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (human) Summary of all recombinase alleles driven by KRT5. Comparative matrix view of recombinase activities Alliance human KRT5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152012 Rock JR, et al., Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5
• All: 3 reference(s)