Sh2b1^tm3(cre)Lr
Targeted Allele Detail

Summary

• Symbol: Sh2b1^tm3(cre)Lr
• Name: SH2B adaptor protein 1; targeted mutation 3, Liangyou Rui
• MGI ID: MGI:6754108
• Synonyms: Sh2b1-Cre
• Gene: Sh2b1 Location: Chr7:126066166-126074596 bp, - strand Genetic Position: Chr7, 69.06 cM
• Alliance: Sh2b1^tm3(cre)Lr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289128
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Sh2b1^tm3(cre)Lr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sh2b1 (MGI:1201407)

• Mutation details: An IRES-EGFP-2A-Cre fragment was inserted at the Sh2b1 locus 3 to the STOP codon through ES cell homologous recombination. GFP levels in Sh2b1-Cre mice were below detection thresholds. (J:289128)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sh2b1 (mouse) Summary of all recombinase alleles driven by Sh2b1. Comparative matrix view of recombinase activities Alliance mouse Sh2b1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2b1 Mutation: 49 strains or lines available

References

• Original: J:289128 Jiang L, et al., Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020 Mar 23;11(1):1517
• All: 1 reference(s)